Calming

Calming

Azelaic Acid / Ivermectin / Metronidazole / Niacinamide / Zinc Pyrithione

Price range: $65.00 through $150.00

Calming is designed to soothe and calm rosacea symptoms by targeting redness, inflammation, and irritation, while addressing underlying causes like skin barrier dysfunction and microbial imbalance.

  • Azelaic Acid — Demonstrated in randomized clinical trials to significantly reduce inflammatory lesions and erythema in papulopustular rosacea compared with placebo, while also improving overall skin texture, pigmentation irregularities, and long-term rosacea symptom control.
  • Ivermectin — Shown in multiple randomized controlled trials and meta-analyses to be superior to metronidazole and azelaic acid in achieving “clear/almost clear” skin outcomes and reducing inflammatory lesions, with additional benefits including improved patient satisfaction and lower relapse rates.
  • Metronidazole — Long established as an effective topical treatment for rosacea with anti-inflammatory and antioxidant properties; clinical studies confirm its role in reducing persistent erythema and papules, as well as improving skin comfort, overall redness control, and daily quality of life.
  • Niacinamide (Vitamin B₃) — Evidence supports its barrier-strengthening, anti-inflammatory, and redness-reducing properties in dermatology, complementing rosacea treatment when combined with other actives, while also minimizing irritation, reducing hyperpigmentation, and enhancing skin’s natural resilience to environmental stressors.
  • Zinc Pyrithione — Recognized for its antibacterial and anti-inflammatory activity; clinical dermatology studies show zinc compounds reduce sebum production and inflammation, supporting overall skin balance, improving skin clarity, and providing additional calming effects for sensitive, redness-prone skin.
  • Cleanse gently with a non-foaming, fragrance-free cleanser.
  • Apply a thin layer of Calming to affected areas once daily (evening application preferred, though ivermectin and azelaic acid are both well-tolerated).
  • Moisturize with a non-comedogenic, soothing moisturizer to reinforce the barrier.
  • Protect during the day with broad-spectrum SPF ≥30, as UV exposure exacerbates rosacea.
  • For sensitive patients, start with application every other day, then increase to daily as tolerated (as done in clinical studies of azelaic acid and ivermectin).
  • Calms redness and soothes inflammation typical in rosacea.
  • Reduces papules and pustules by targeting underlying microbial and mite triggers.
  • Improves skin texture and tone, reinforcing skin barrier with niacinamide.
  • Gentle formula ideal for sensitive or reactive skin types.

Q: Do I need a prescription for Calming?
A: Yes. Calming contains prescription-strength actives such as ivermectin, metronidazole, and azelaic acid, so it should be used under the guidance of our licensed healthcare provider.

Q: Can I use Calming during the day?
A: Calming can be used either morning or evening, but dermatologists often recommend evening application. If applied during the day, always follow with a broad-spectrum SPF 30 or higher, since rosacea-prone skin is highly sensitive to UV exposure.

Q: Is Calming safe to use with makeup?
A: Yes. Once Calming has fully absorbed into the skin and is followed by a moisturizer and sunscreen, makeup can be applied without reducing the treatment’s effectiveness.

Q: Who should avoid using Calming?
A: Individuals allergic to any of its ingredients, or those with extremely compromised skin barriers (such as open wounds or severe eczema), should avoid use. Pregnant or breastfeeding patients should consult our healthcare provider before starting.

Q: Can Calming help with rosacea flare-up prevention?
A: Yes. Regular daily use helps reduce inflammatory triggers, balance skin, and minimize recurrence of flare-ups, making it an effective long-term management option for rosacea-prone skin.

  1. Feng, X. (2024). Azelaic Acid: Mechanisms of Action and Clinical Applications. PMC.
  2. King, S. (2023). A systematic review to evaluate the efficacy of azelaic acid in acne, rosacea, melasma, and skin aging. Journal of Cosmetic Dermatology.
  3. Fyrand, O. (1999). Double‑blind comparison of azelaic acid 20% cream vs. vehicle in the treatment of papulopustular rosacea. Acta Derm Venereol, 79, 456–459.
  4. Ebbelaar, C. C. F. (2018). Topical ivermectin in the treatment of papulopustular rosacea. PMC.
  5. Schaller, M., et al. (2016). Superior Efficacy with Ivermectin 1% Cream Compared to Metronidazole 0.75% Cream. PMC.
  6. Siddiqui, K., et al. (2016). The efficacy, safety, and tolerability of ivermectin compared with other topical treatments: a network meta-analysis. SpringerPlus, 5.
  7. Yeh, M. C. H., et al. (2022). Topical Metronidazole Versus Ivermectin… A Split‑face Study. Acta Dermato‑Venereologica (Medical Journals Sweden).

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Revitalize your hair with targeted solutions like Hair Force One and GHK-Cu Peptide

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Eternelle - Health and Wellness

Orange County, CA
(Virtual Services Nationwide)

(949) 990-4490

hello@eternellehealth.com

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Eternelle - Health and Wellness

Orange County, CA
(Virtual Services Nationwide)

(949) 990-4490

hello@eternellehealth.com

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