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Stella+

Ideal for

  • Individuals with aging skin
  • Those with fine lines and wrinkles
  • People needing skin rejuvenation
  • Individuals improving skin firmness

Anti-Aging

Stella+

GHK-Cu / Estriol / Tretinoin / Niacinamide

$276.00

Stella+ brings together copper peptide GHK-Cu, estriol, and tretinoin in a nighttime cream for skin experiencing visible changes over time. The formula combines tretinoin-driven skin renewal with peptide-focused skin conditioning, a hormone-based component, and niacinamide for barrier support. Our healthcare provider can determine whether this multi-ingredient approach fits your individual skin needs.ment that improves skin elasticity, smooths fine lines, and promotes cellular renewal for a youthful complexion.

  • Renewal Meets Peptide Care – Pairs tretinoin’s established skin-turnover activity with GHK-Cu, a copper peptide studied for its role in skin-related biological processes.
  • Addresses Changing Skin Texture – Tretinoin can help improve certain texture changes and visible signs associated with photoaging.
  • Hormone-Focused Skin Care – Estriol provides a distinct hormone-based component that may be considered for certain age-related skin concerns.
  • Barrier Support Built In – Niacinamide helps maintain the skin barrier and moisture balance while complementing the more active ingredients.
  • GHK-Cu is a naturally occurring copper-binding peptide. It has been studied for its involvement in biological processes related to skin and tissue remodeling, although clinical evidence for cosmetic outcomes from compounded topical GHK-Cu remains limited.
  • Estriol is a form of estrogen that has been studied topically in relation to certain age-related changes in skin. Its use is individualized because it is hormonally active.
  • Tretinoin promotes skin cell turnover and has established dermatologic use for improving certain signs of photoaging and changes in skin texture.
  • Niacinamide helps maintain skin-barrier function and moisture retention, providing complementary support alongside the formula’s active ingredients.
  • Make Stella+ part of your evening skincare routine as directed. Apply a pea-sized amount or thin layer to the prescribed treatment area, avoiding the eyes, lips, and irritated skin. Because Stella+ contains tretinoin and estriol, our healthcare provider may tailor application frequency according to skin tolerance and individual clinical considerations. Keep refrigerated as instructed by the dispensing pharmacy.

Q: What makes Stella+ different from other nighttime skin treatments?
A: It combines four different components within one formula: GHK-Cu for peptide-focused skin conditioning, tretinoin for cell turnover, estriol for a hormone-based approach, and niacinamide for skin-barrier support.

Q: What is GHK-Cu?
A: GHK-Cu is a naturally occurring peptide that binds copper. It has been studied for its involvement in several biological processes related to skin and tissue remodeling. Research interest is promising, but results from this specific compounded formula should not be assumed or guaranteed.

Q: Why pair GHK-Cu with tretinoin?
A: The ingredients have different roles. Tretinoin has established effects on skin cell turnover, while GHK-Cu is included for its peptide-related skin-conditioning properties. Combining them provides a multi-ingredient approach rather than relying on one mechanism.

Q: What does estriol add to Stella+?
A: Estriol introduces a hormone-based component. Topical estriol has been studied for certain age-related skin characteristics, but our healthcare provider must determine whether hormone-containing skincare is appropriate for you.

Q: Is Stella+ intended to regenerate the skin?
A: We would not describe it as a proven skin-regeneration treatment. Its ingredients have been studied for processes involving skin renewal, remodeling, and appearance, but individual cosmetic outcomes from this specific formulation have not been established.

Q: What should I know when starting Stella+?
A: Tretinoin can initially cause dryness, peeling, redness, or sensitivity. Our healthcare provider may adjust application frequency as your skin adapts. Because Stella+ also contains estriol, relevant health history should be reviewed before and during treatment.

  1. Pickart, L., & Margolina, A. (2024). Anti-aging activity of GHK-Cu peptide: The skin and beyond [PDF]. Retrieved from Marcio Rubin.
  2. Pickart, L. (2018). Regenerative and protective actions of the GHK-Cu peptide: Clinical studies in aging skin. International Journal of Molecular Sciences. Retrieved from PubMed Central (PMC).
  3. Rzepecki, A. K., et al. (2019). Estrogen-deficient skin: The role of topical therapy. Clinical, Cosmetic and Investigational Dermatology. Retrieved from PubMed Central (PMC).
  4. Bravo, B., et al. (2024). Dermatological changes during menopause and HRT. Cosmetics (MDPI). Retrieved from MDPI.
  5. Ogórek, K., et al. (2025). Insights into skin permeation of hydrophilic cosmetic actives like GHK-Cu. Molecules (MDPI). Retrieved from MDPI.
  6. DrOracle.ai. (2025, July 2). Is GHK-Cu more effective when combined with tretinoin (Retin-A)? Retrieved from DrOracle.ai.

A medical intake form is required prior to receiving a prescription. A licensed healthcare provider will review it and determine your eligibility for this product. Click the Get Started button to fill up your intake form.​

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Orange County, CA
(Virtual Services Nationwide)

(949) 990-4490

hello@eternellehealth.com

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