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Vitality

Ideal for

  • Individuals with aging skin
  • Those with fine lines
  • People needing skin renewal
  • Individuals improving skin texture

Anti-Aging

Vitality

Estriol / Tretinoin with Niacinamide

$154.00

Vitality pairs estriol with tretinoin in a streamlined nighttime cream for skin experiencing changes in texture, moisture, and appearance over time. Tretinoin encourages skin renewal, while niacinamide provides complementary barrier support. Estriol adds a hormone-based component that may be considered for certain age-related skin concerns under the guidance of our healthcare provider.

  • Encourages Skin Renewal – Tretinoin promotes cell turnover, helping address changes in texture and the appearance of photoaged skin.
  • Age-Related Skin Care – Estriol introduces a hormone-based approach that may be considered for certain changes that occur in skin over time.
  • Maintains the Skin Barrier – Niacinamide helps support barrier function and moisture retention alongside the formula’s active ingredients.
  • Streamlined Nighttime Routine – Combines renewal, barrier support, and hormone-focused care in one prescribed evening treatment.
  • Estriol is a form of estrogen. Topical estriol has been studied for its potential effects on certain characteristics of aging skin, including moisture and elasticity, although its use for cosmetic skin aging is not FDA-approved.
  • Tretinoin is a topical retinoid with established effects on skin cell turnover. It is used in dermatologic care to address photoaging and changes in skin texture.
  • Niacinamide is a form of vitamin B3 that helps reinforce the skin barrier, reduce moisture loss, and complement a skincare routine containing active ingredients.

In the evening, smooth a pea-sized amount or thin layer of Vitality over the treatment area as prescribed. Avoid the eyes, lips, and irritated skin. If you are new to tretinoin, our healthcare provider may recommend a gradual application schedule based on how your skin responds.

Q: What skin concerns is Vitality designed around?
A: Vitality is intended for a personalized skincare plan addressing concerns such as changing texture, photoaging, moisture, and other visible age-related changes.

Q: Why combine estriol and tretinoin?
A: The two ingredients approach the skin differently. Tretinoin promotes cell turnover, while estriol introduces hormone-related activity that has been studied in relation to certain characteristics of aging skin.

Q: How does Vitality differ from Vitality Plus?
A: Vitality contains estriol, tretinoin, and niacinamide. Vitality Plus adds finasteride, giving that formula an additional anti-androgenic component. Our healthcare provider can determine which formulation, if either, is appropriate for your needs.

Q: Will tretinoin make my skin peel?
A: Some people experience dryness, peeling, redness, or sensitivity when beginning tretinoin. These effects can vary, and our healthcare provider may modify application frequency according to your tolerance.

Q: Why is niacinamide included?
A: Niacinamide helps support the skin barrier and moisture retention, making it a useful complement to a formula containing tretinoin.

Q: Is Vitality intended for ongoing use?
A: Treatment may continue for approximately 3–6 months or longer when appropriate. Our healthcare provider can periodically reassess your skin’s response and determine whether your regimen should continue or change.

  1. Sitohang, I. B. S., Makes, W. I., Sandora, N., & Suryanegara, J. (2022). Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials. PMC.
  2. Issa, N. (2025). Recommendations to Improve Outcomes in Acne and Aging Skin: The efficacy of tretinoin 0.025% gel. PMC.
  3. Lephart, E. D. (2025). Bioactives for Estrogen‑Deficient Skin: Topical and Oral Approaches. PMC. 
  4. Smith, D. (2025, July 29). Healthy Aging Spotlight: Estrogen Face Cream & Your Skin. Dr. Smith’s ND Blog.
  5. Hussen, N. H. A. (2025). Role of antioxidants in skin aging: Vitamin C and alpha-lipoic acid. ScienceDirect.
  6. Speeckaert, R., & co-authors. (2023). The impact of antioxidants on vitiligo and melasma. MDPI Antioxidants. 
  7. Turner, C. (2024). Anti‑aging: Estrogen and a Woman’s Skin. PCCA Rx Blog.
  8. DrOracle.ai (2025, July 14). Mechanism of Action of Topical Estriol 0.3% for Anti‑Aging. DrOracle.ai. 

A medical intake form is required prior to receiving a prescription. A licensed healthcare provider will review it and determine your eligibility for this product. Click the Get Started button to fill up your intake form.​

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Orange County, CA
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Eternelle - Health and Wellness

Orange County, CA
(Virtual Services Nationwide)

(949) 990-4490

hello@eternellehealth.com

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