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Flawless

Ideal for

  • Individuals with oily skin
  • Those with enlarged pores
  • People with hormonal acne
  • Individuals seeking smoother skin texture

Acne

Flawless

Azelaic Acid / Metformin / Progesterone / Spironolactone

Price range: $154.00 through $299.00

Flawless takes a hormone-focused approach to persistent acne by combining azelaic acid and spironolactone with metformin and progesterone in a customized topical formula. The ingredients interact with different pathways that may be considered when hormonal or metabolic factors are relevant to recurring breakouts. Because evidence varies considerably among the individual ingredients when used topically for acne, our healthcare provider will determine whether this combination is appropriate for your specific acne pattern and health history.

  • Hormone-Focused Acne Care – Incorporates ingredients selected for pathways that may be relevant when hormonal factors contribute to recurring breakouts.
  • Anti-Androgenic Approach – Spironolactone provides activity against androgen signaling, a factor that can contribute to acne in some individuals.
  • Addresses Multiple Factors – Combines anti-inflammatory, anti-androgenic, metabolic, and hormone-related components within one individualized formulation.
  • Personalized Treatment Strategy – Gives our healthcare provider an option to consider when an individual’s acne pattern and clinical history suggest a more customized approach may be appropriate.
  • Azelaic Acid has anti-inflammatory and antimicrobial properties and is used topically in dermatologic care for acne and certain pigmentation concerns.
  • Metformin is best established as an oral medication that affects glucose metabolism and insulin sensitivity. It has also generated research interest in dermatologic and hormone-related conditions, but topical metformin for acne is not an established FDA-approved treatment.
  • Progesterone is a naturally occurring steroid hormone involved in reproductive and other physiological processes. Its inclusion in a topical acne formulation represents an individualized hormone-based approach rather than an established standard acne therapy.
  • Spironolactone has anti-androgenic activity and may be used topically when androgen signaling is considered relevant to hormonally influenced breakouts.
  • Apply a thin layer of Flawless to the acne-affected areas identified in your treatment plan, typically once or twice daily when prescribed that way. Avoid the eyes, lips, broken skin, and other sensitive areas. Because the formula contains hormone-active ingredients, use only according to the schedule established by our healthcare provider and do not change the amount or frequency without guidance.

Q: What makes Flawless different from other acne creams?
A: Flawless is more hormone-focused than a conventional acne formula. Along with azelaic acid and spironolactone, it contains metformin and progesterone, making medical evaluation particularly important before treatment.

Q: Why is spironolactone included?
A: Spironolactone has anti-androgenic activity. Androgens can influence sebaceous gland activity and acne development, so our healthcare provider may consider an anti-androgenic approach when breakouts appear hormonally influenced.

Q: Why does an acne formula contain metformin?
A: Metformin is primarily known for its systemic effects on glucose metabolism and insulin sensitivity. Researchers have also explored its relevance to dermatologic and hormone-related conditions. Evidence for topical metformin in acne remains limited, however, so its inclusion should not be interpreted as an established acne treatment.

Q: What role does progesterone have in Flawless?
A: Progesterone is a hormone involved in numerous physiological processes. Its topical use for acne is not an established FDA-approved treatment, so its inclusion is based on an individualized treatment approach determined by our healthcare provider.

Q: Is Flawless appropriate for every type of acne?
A: No. Acne can have many contributing factors. Our healthcare provider will consider your breakout pattern, medical history, medications, and other relevant information before determining whether this hormone-focused formulation is appropriate.

Q: When should treatment be evaluated?
A: Your current protocol uses approximately 8–12 weeks as an initial treatment period. Our healthcare provider can then evaluate your response, tolerance, and whether the treatment should continue or change.

  1. Bubna, A. K. (2016). Metformin—for the dermatologist. Indian Journal of Pharmacology, 48(1), 4–10.
  2. Kelly, C. J., & Gordon, D. (2002). The effect of metformin on hirsutism in polycystic ovary syndrome. European Journal of Endocrinology, 147(2), 217-221. Retrieved from PubMed.
  3. Rezvanian, H., Adibi, N., Siavash, M., Kachuei, A., Shojaee‑Moradie, F., & Asilian, A. (2009). Increased insulin sensitivity by metformin enhances intense‑pulsed‑light‑assisted hair removal in patients with polycystic ovary syndrome. Dermatology, 218(3), 231–236.
  4. Stamatiadis, D., Bulteau‑Portois, M. C., & Mowszowicz, I. (1988). Inhibition of 5 alpha‑reductase activity in human skin by zinc and azelaic acid. British Journal of Dermatology, 119(5), 627–632.
  5. Sachdeva S. Hirsutism: evaluation and treatment. Indian J Dermatol. 2010;55(1):3-7. doi: 10.4103/0019-5154.60342.
  6. Mayo Clinic. (2025, February 1). Azelaic acid (topical route) – Side effects & dosage. Retrieved from Mayo Clinic.
  7. Kolatorova, L., Vitku, J., Suchopar, J., Hill, M., & Parizek, A. (2022). Progesterone: A Steroid with Wide Range of Effects in Physiology as Well as Human Medicine. International Journal of Molecular Sciences, 23(14), 7989. National Library of Medicine.

A medical intake form is required prior to receiving a prescription. A licensed healthcare provider will review it and determine your eligibility for this product. Click the Get Started button to fill up your intake form.​

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Orange County, CA
(Virtual Services Nationwide)

(949) 990-4490

hello@eternellehealth.com

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